Pitavastatin inhibits proinflammatory cytokines and provides improvement in terms of its motor function in secondary injuries of the spinal cord mouse models

Background: Statins are hydroxymethylglutaryl coenzyme A reductase inhibitors that reduce intracellular cholesterol synthesis by competitively inhibiting endogenous cholesterol synthesis rate limiting enzymes. Currently they are most used in the prevention of coronary heart disease. Aside on their cholesterol-lowering effect, statins are also anti-inflammatory in terms of their effects. Recent studies have shown that statins can produce anti-inflammatory effects in acute models of injuries in the